Vanessa J Lazaro-Camp, Kiarash Salari, Xiangbing Meng, Shujie Yang: SETDB1 in cancer: overexpression and its therapeutic implications. Am J Cancer Res 2021;11(5):1803-1827. (Full text, PDF)
Chella Perumal Palanisamy, Bo Cui, Hongxia Zhang, Mani Panagal, Sivagurunathan Paramasivam, Uma Chinnaiyan, Selvaraj Jeyaraman, Karthigeyan Murugesan, Mauricio Rostagno, Vijayakumar Sekar, Srinivasa Prabhu Natarajan: Anti-ovarian cancer potential of phytocompound and extract from South African medicinal plants and their role in the development of chemotherapeutic agents. Am J Cancer Res 2021;11(5):1828-1844. (Full text, PDF)
Ming Yang, Chunye Zhang: The role of liver sinusoidal endothelial cells in cancer liver metastasis. Am J Cancer Res 2021;11(5):1845-1860. (Full text, PDF)
Paulius Gibieža, Vilma Petrikaitė: The dual functions of Rab11 and Rab35 GTPases-regulation of cell division and promotion of tumorigenicity. Am J Cancer Res 2021;11(5):1861-1872. (Full text, PDF)
Min Liu, Hongzhe Shi, Jiaqing Yan, Yuan Zhang, Yinglin Ma, Kaidi Le, Zhongdong Li, Nianzeng Xing, Guohui Li: Gene polymorphism-related differences in the outcomes of abiraterone for prostate cancer: a systematic overview. Am J Cancer Res 2021;11(5):1873-1894. (Full text, PDF)
Jia-Fu Ying, Ze-Bei Lu, Luo-Qin Fu, Yu Tong, Zhen Wang, Wei-Fen Li, Xiao-Zhou Mou: The role of iron homeostasis and iron-mediated ROS in cancer. Am J Cancer Res 2021;11(5):1895-1912. (Full text, PDF)
Mengna Zhang, Lingxian Zhang, Ruoxuan Hei, Xiao Li, Haonan Cai, Xuan Wu, Qiping Zheng, Cheguo Cai: CDK inhibitors in cancer therapy, an overview of recent development. Am J Cancer Res 2021;11(5):1913-1935. (Full text, PDF)
Longfei Liu, Xiaoping Yi, Can Lu, Yingxian Pang, Xiongbing Zu, Minfeng Chen, Xiao Guan: Background, applications and challenges of radiogenomics in genitourinary tumor. Am J Cancer Res 2021;11(5):1936-1945. (Full text, PDF)
Yuanfeng Gou, Fei Li, Xiaqin Huo, Chunyan Hao, Xiaojuan Yang, Yaping Pei, Na Li, Huiling Liu, Bingdong Zhu: ENO1 monoclonal antibody inhibits invasion, proliferation and clone formation of cervical cancer cells. Am J Cancer Res 2021;11(5):1946-1961. (Full text, PDF)
Xueke Qian, Hongbo Qu, Fan Zhang, Shujia Peng, Dongwei Dou, Yunqing Yang, Yichao Ding, Mingwei Xie, Huaying Dong, Yue Liao, Mingli Han: Exosomal long noncoding RNA AGAP2-AS1 regulates trastuzumab resistance via inducing autophagy in breast cancer. Am J Cancer Res 2021;11(5):1962-1981. (Full text, PDF)
Tong Chen, Jianglong Chen, Xiuhao Zhao, Jing Zhou, Qingfeng Sheng, Linlin Zhu, Zhibao Lv: βKlotho, a direct target of miR-206, contributes to the growth of hepatoblastoma through augmenting PI3K/Akt/mTOR signaling. Am J Cancer Res 2021;11(5):1982-2004. (Full text, PDF)
Jinyang Wang, Yuan Zhang, Yi Xiao, Xiangliang Yuan, Ping Li, Xiao Wang, Yimin Duan, Victoria L Seewaldt, Dihua Yu: Boosting immune surveillance by low-dose PI3K inhibitor facilitates early intervention of breast cancer. Am J Cancer Res 2021;11(5):2005-2024. (Full text, PDF)
Yumin Qiu, Hengqing Zhu, Debin Xu, Qian Feng, Chongyu Wen, Yunyan Du, Mingfeng Xiang, Leifeng Chen, Xiaogang Peng: RING-finger protein 6 enhances c-Myc-mediated Warburg effect by promoting MAD1 degradation to facilitate pancreatic cancer metastasis. Am J Cancer Res 2021;11(5):2025-2043. (Full text, PDF)
Xuxiao Chen, Ao Huang, Yupeng Wang, Feiyu Chen, Bo Hu, Xin Zhang, Yunfan Sun, Jian Wang, Jianwen Cheng, Pengxiang Wang, Yuan Ji, Shuangjian Qiu, Jia Fan, Jian Zhou, Xinrong Yang: BRCA1-associated protein 1 serves as a tumor suppressor in hepatocellular carcinoma by deubiquitinating and stabilizing PTEN. Am J Cancer Res 2021;11(5):2044-2061. (Full text, PDF)
Siyuan Yan, Qianqian Li, Deru Zhang, Xiaowen Wang, Yang Xu, Cong Zhang, Dongli Guo, Yonghua Bao: Necroptosis pathway blockage attenuates PFKFB3 inhibitor-induced cell viability loss and genome instability in colorectal cancer cells. Am J Cancer Res 2021;11(5):2062-2080. (Full text, PDF)
Kinga Bednarek, Magdalena Kostrzewska-Poczekaj, Adam Ustaszewski, Joanna Janiszewska, Katarzyna Kiwerska, Julia Paczkowska, Reidar Grenman, Maciej Giefing, Malgorzata Jarmuz-Szymczak: Laryngeal squamous cell carcinoma cell lines show high tolerance for siRNA-mediated CDK1 knockdown. Am J Cancer Res 2021;11(5):2081-2094. (Full text, PDF)
Xiaochuang Feng, Hongming Li, Xinquan Lu, Xiaojiang Yi, Jin Wan, Weilin Liao, Jiahao Wang, Yisen Ke, Ping Tan, Jialiang Chen, Tianwen Liu, Xiaoyan Hong, Dechang Diao: Regional lymph nodes distribution pattern in central area of right-sided colon cancer: in-vivo detection and the update on the clinical exploration. Am J Cancer Res 2021;11(5):2095-2105. (Full text, PDF)
Kai Wang, Yanhua Qi, Xu Wang, Yushuai Liu, Min Zhao, Ding Zhou, Yu Zhang, Yan Wang, Rutong Yu, Xiuping Zhou: GOLPH3 promotes glioma progression by enhancing PHB2-mediated autophagy. Am J Cancer Res 2021;11(5):2106-2123. (Full text, PDF)
Taoqiong Li, Li Lin, Qin Liu, Wujiang Gao, Lu Chen, Chunli Sha, Qi Chen, Wenlin Xu, Yuefeng Li, Xiaolan Zhu: Exosomal transfer of miR-429 confers chemoresistance in epithelial ovarian cancer. Am J Cancer Res 2021;11(5):2124-2141. (Full text, PDF)
Shaorong Zhao, Yannan Geng, Lixia Cao, Qianxi Yang, Teng Pan, Dongdong Zhou, Jingjing Liu, Zhendong Shi, Jin Zhang: Deciphering the performance of polo-like kinase 1 in triple-negative breast cancer progression according to the centromere protein U-phosphorylation pathway. Am J Cancer Res 2021;11(5):2142-2158. (Full text, PDF)
Lian Zhang, Ping Yang, Jing Wang, Qi Liu, Tian Wang, Yaling Wang, Feng Lin: MiR-22 regulated T cell differentiation and hepatocellular carcinoma growth by directly targeting Jarid2. Am J Cancer Res 2021;11(5):2159-2173. (Full text, PDF)
Marco De Martino, Pedro Nicolau-Neto, Luis Felipe Ribeiro Pinto, Alexandra Traverse-Glehen, Emmanuel Bachy, Vincenzo Gigantino, Rossella De Cecio, Francesco Bertoni, Paolo Chieffi, Alfredo Fusco, Francesco Esposito: HMGA1 induces EZH2 overexpression in human B-cell lymphomas. Am J Cancer Res 2021;11(5):2174-2187. (Full text, PDF)
Jie Hao, Heng Lu, Debarati Mukherjee, Lin Yu, Jihe Zhao: Role of krüppel-like factor 8 for therapeutic drug-resistant multi-organ metastasis of breast cancer. Am J Cancer Res 2021;11(5):2188-2201. (Full text, PDF)
Vivek Ramakrishnan, Christopher de Haydu, Peter Wilkinson, Urvashi Hooda, Bhuwan Giri, Janneth M Oleas, Veronica Rive, Sabita Roy, Vikas Dudeja, Brian Slomovitch, Ashok Saluja, Sundaram Ramakrishnan: Minnelide, a prodrug, inhibits cervical cancer growth by blocking HPV-induced changes in p53 and pRb. Am J Cancer Res 2021;11(5):2202-2214. (Full text, PDF, Video S1, S2, S3, S4)
Ae Ryang Jung, Ga Eun Kim, Mee Young Kim, U-Syn Ha, Sung-Hoo Hong, Ji Youl Lee, Sae Woong Kim, Yong Hyun Park: HMGB1 promotes tumor progression and invasion through HMGB1/TNFR1/NF-κB axis in castration-resistant prostate cancer. Am J Cancer Res 2021;11(5):2215-2227. (Full text, PDF)
Yuan-Tzu Lan, Shih-Ching Chang, Pei-Ching Lin, Chien-Hsing Lin, Wen-Yi Liang, Wei-Shone Chen, Jeng-Kai Jiang, Shung-Haur Yang, Jen-Kou Lin: High concordance of mutation patterns in 10 common mutated genes between tumor tissue and cell-free DNA in metastatic colorectal cancer. Am J Cancer Res 2021;11(5):2228-2237. (Full text, PDF)
Chengjie Mei, Xiang Jiang, Yang Gu, Xiaoling Wu, Weijie Ma, Xi Chen, Ganggang Wang, Ye Yao, Yingyi Liu, Zhonglin Zhang, Yufeng Yuan: YY1-mediated reticulocalbin-2 upregulation promotes the hepatocellular carcinoma progression via activating MYC signaling. Am J Cancer Res 2021;11(5):2238-2251. (Full text, PDF)
Ahmed H Mekkawy, Krishna Pillai, Samina Badar, Javed Akhter, Kevin Ke, Sarah J Valle, David L Morris: Addition of bromelain and acetylcysteine to gemcitabine potentiates tumor inhibition in vivo in human colon cancer cell line LS174T. Am J Cancer Res 2021;11(5):2252-2263. (Full text, PDF)
Hailei Du, Lihua Liu, Hongliang Liu, Sheng Luo, Edward F Patz Jr, Carolyn Glass, Li Su, Mulong Du, David C Christiani, Qingyi Wei: Genetic variants of DOCK2, EPHB1 and VAV2 in the natural killer cell-related pathway are associated with non-small cell lung cancer survival. Am J Cancer Res 2021;11(5):2264-2277. (Full text, PDF)
Yun-Ju Lai, Chi-Hong Chao, Chun-Che Liao, Te-An Lee, Jung-Mao Hsu, Wen-Cheng Chou, Jyun Wang, Hsiang-Chi Huang, Shing-Jyh Chang, Yi-Ling Lin, Chia-Wei Li: Epithelial-mesenchymal transition induced by SARS-CoV-2 required transcriptional upregulation of Snail. Am J Cancer Res 2021;11(5):2278-2290. (Full text, PDF)
Yun-Long Wang, Ming-Biao Wei, Wan-Wen Zhao, Li-Li Feng, Xin-Ke Yin, Shao-Mei Bai, Xiang-Bo Wan, Mien-Chie Hung, Andrew Z Zou, Michael H Wang, Jian Zheng, Caolitao Qin, Xin-Juan Fan: Glycosylation of Siglec15 promotes immunoescape and tumor growth. Am J Cancer Res 2021;11(5):2291-2302. (Full text, PDF)
Francesca Ricci, Alessandro Corbelli, Roberta Affatato, Rosaria Chilà, Michela Chiappa, Laura Brunelli, Robert Fruscio, Roberta Pastorelli, Fabio Fiordaliso, Giovanna Damia: Mitochondrial structural alterations in ovarian cancer patient-derived xenografts resistant to cisplatin. Am J Cancer Res 2021;11(5):2303-2311. (Full text, PDF)
Keiji Nishibeppu, Shuhei Komatsu, Toshiyuki Kosuga, Takeshi Kubota, Kazuma Okamoto, Hirotaka Konishi, Atsushi Shiozaki, Hitoshi Fujiwara, Eigo Otsuji: Cumulative total S-1 dose in adjuvant chemotherapy affects the long-term outcome following curative gastrectomy for gastric cancer. Am J Cancer Res 2021;11(5):2312-2318. (Full text, PDF)
Wei Teng, Chen-Chun Lin, Ming-Mo Ho, Kar-Wai Lui, Sheng-Fu Wang, Chao-Wei Hsu, Shi-Ming Lin: Alpha-fetoprotein response at different time-points is associated with efficacy of nivolumab monotherapy for unresectable hepatocellular carcinoma. Am J Cancer Res 2021;11(5):2319-2330. (Full text, PDF)
Shi-Heng Wang, Shu-Pin Huang, Yi-Jiun Pan, Po-Chang Hsiao, Chia-Yang Li, Lih-Chyang Chen, Chia-Cheng Yu, Chao-Yuan Huang, Victor C Lin, Te-Ling Lu, Bo-Ying Bao: Association between the polygenic liabilities for prostate cancer and breast cancer with biochemical recurrence after radical prostatectomy for localized prostate cancer. Am J Cancer Res 2021;11(5):2331-2342. (Full text, PDF)
Anshu Khanna, Eric M Sturgis, Kristina R Dahlstrom, Li Xu, Qingyi Wei, Guojun Li, Neil D Gross: Association of pretreatment body mass index with risk of head and neck cancer: a large single-center study. Am J Cancer Res 2021;11(5):2343-2350. (Full text, PDF)
Jianwei Wang, Harry Hua-Xiang Xia, Yuanyuan Zhang, Lanjing Zhang: Trends in treatments for prostate cancer in the United States, 2010-2015. Am J Cancer Res 2021;11(5):2351-2368. (Full text, PDF)
