Ling-Chu Chang, Shih-Kai Chiang, Shuen-Ei Chen, Mien-Chie Hung: Targeting 2-oxoglutarate dehydrogenase for cancer treatment. Am J Cancer Res 2022;12(4):1436-1455. (Full text, PDF)
Junjie Gao, Dandan Yang, Ruoxue Cao, Hua Huang, Jia Ma, Zhiwei Wang, Jun Xia, Xueshan Pan: The role of Fbxo5 in the development of human malignant tumors. Am J Cancer Res 2022;12(4):1456-1464. (Full text, PDF)
Bang-Hung Liu, Tein-Ming Yuan, Chih-Jou Huang, Duan-Ting Hsu, Shi-Wen Chen, Nai-Wan Hsiao, Sheng-Chih Lin, Shu-Wan Wu, Yi-Mei J Lin, Show-Mei Chuang: DNA repair proteins as the targets for paroxetine to induce cytotoxicity in gastric cancer cell AGS. Am J Cancer Res 2022;12(4):1465-1483. (Full text, PDF)
Tengyang Fan, Guojun Jiang, Rongshu Shi, Ronghua Yu, Xue Xiao, Di Ke: Construction of AP003469.4-miRNAs-mRNAs ceRNA network to reveal potential biomarkers for hepatocellular carcinoma. Am J Cancer Res 2022;12(4):1484-1501. (Full text, PDF, Supplementary Tables 1, 2, 3)
Wenjuan Pu, Lei Xue, Ziqi Han, Lei Yang, Yubao Wang, Nansheng Wan, Jing Feng: The efficacy and mechanism of thoracic photodynamic therapy mediated by hematoporphyrin injection on disseminated pleural malignancies of Lewis lung carcinoma in mice. Am J Cancer Res 2022;12(4):1502-1510. (Full text, PDF)
Wanli Yang, Liaoran Niu, Xinhui Zhao, Lili Duan, Xiaoqian Wang, Yiding Li, Junfeng Chen, Wei Zhou, Yujie Zhang, Daiming Fan, Liu Hong: Pyroptosis impacts the prognosis and treatment response in gastric cancer via immune system modulation. Am J Cancer Res 2022;12(4):1511-1534. (Full text, PDF)
Guangyu Cheng, Lin Li, Qingjie Li, Shulin Lian, Hongbo Chu, Yunlu Ding, Chikun Li, Yan Leng: β-elemene suppresses tumor metabolism and stem cell-like properties of non-small cell lung cancer cells by regulating PI3K/AKT/mTOR signaling. Am J Cancer Res 2022;12(4):1535-1555. (Full text, PDF)
Yuan-Sheng Hsu, Pei-Jung Wu, Yung-Ming Jeng, Chun-Mei Hu, Wen-Hwa Lee: Differential effects of glucose and N-acetylglucosamine on genome instability. Am J Cancer Res 2022;12(4):1556-1576. (Full text, PDF)
Juncheng Cui, Dylan Dean, Francis J Hornicek, Raphael E Pollock, Robert M Hoffman, Zhenfeng Duan: ATR inhibition sensitizes liposarcoma to doxorubicin by increasing DNA damage. Am J Cancer Res 2022;12(4):1577-1592. (Full text, PDF)
Yasuaki Uemoto, Eriko Katsuta, Naoto Kondo, Yumi Wanifuchi-Endo, Takashi Fujita, Tomoko Asano, Tomoka Hisada, Mitsuo Terada, Akiko Kato, Katsuhiro Okuda, Hiroshi Sugiura, Masayuki Komura, Hiroyuki Kato, Satoshi Osaga, Satoru Takahashi, Tatsuya Toyama: Low HECTD1 mRNA expression is associated with poor prognosis and may be correlated with increased mitochondrial respiratory function in breast cancer. Am J Cancer Res 2022;12(4):1593-1605. (Full text, PDF)
Chung-Wei Su, Ming-Mo Hou, Pei-Wei Huang, Yung-Chih Chou, Bing-Shen Huang, Jeng-Hwei Tseng, Chao-Wei Hsu, Tung-Chieh Chang, Shi-Ming Lin, Chen-Chun Lin: Proton beam radiotherapy combined with anti-PD1/PDL1 immune checkpoint inhibitors for advanced hepatocellular carcinoma. Am J Cancer Res 2022;12(4):1606-1620. (Full text, PDF)
Jiaqi Jiao, Linlin Ji, Xianju Li, Zhan Gao, Guangshun Wang, Jun Qin, Yini Wang, Yi Wang: Dynamic proteomic change of tumor and immune organs in an immune-competent hepatocellular carcinoma mouse model. Am J Cancer Res 2022;12(4):1621-1634. (Full text, PDF, Supplementary Tables 1, 2, 3, 4, 5, 6)
Xue-Song Sun, Sai-Lan Liu, Si-Yi Xie, Rui Sun, Dong-Hua Luo, Qiu-Yan Chen, Hai-Qiang Mai: Construction and validation of a biochemical signature to predict the prognosis and the benefit of induction chemotherapy in patients with nasopharyngeal carcinoma. Am J Cancer Res 2022;12(4):1635-1647. (Full text, PDF)
Weihao Li, Jian Zhou, Tianqi Zhang, Yi Tai, Yanbo Xu, Yanfang Bai, Yu Jiang, Zhenhai Lu, Liren Li, Jinhua Huang, Zhizhong Pan, Xiaojun Wu, Jianhong Peng, Junzhong Lin: A novel score system for predicting conversion to no evidence of Disease (C-NED) in initially unresectable colorectal cancer liver metastases. Am J Cancer Res 2022;12(4):1648-1659. (Full text, PDF)
Fei Ye, Xiaoxia Han, Yonzhao Shao, Jingzhi Lo, Fengxia Zhang, Jinhua Wang, Jonathan Melamed, Fang-Ming Deng, Karen S Sfanos, Angelo De Marzo, Guoping Ren, Dongwen Wang, David Zhang, Peng Lee: Identification of novel biomarkers differentially expressed between African-American and Caucasian-American prostate cancer patients. Am J Cancer Res 2022;12(4):1660-1670. (Full text, PDF)
Parham Jabbarzadeh Kaboli, Shima Shabani, Sagar Sharma, Minoo Partovi Nasr, Hirohito Yamaguchi, Mien-Chie Hung: Shedding light on triple-negative breast cancer with Trop2-targeted antibody-drug conjugates. Am J Cancer Res 2022;12(4):1671-1685. (Full text, PDF)
Chih-Ming Ho, Fa-Kung Lee, Ting-Lin Yen, Shih-Hung Huang, Wen-Fang Cheng: Everolimus combined with 5-aza-2-deoxycytidine generated potent anti-tumor effects on ovarian clear cell cancer stem-like/spheroid cells by inhibiting the COL6A3-AKT-mTOR pathway. Am J Cancer Res 2022;12(4):1686-1706. (Full text, PDF)
Yao Zhang, Xiaopei Hao, Guoyong Han, Yiwei Lu, Zhiqiang Chen, Long Zhang, Jindao Wu, Xuehao Wang: E2F1-mediated GINS2 transcriptional activation promotes tumor progression through PI3K/AKT/mTOR pathway in hepatocellular carcinoma. Am J Cancer Res 2022;12(4):1707-1726. (Full text, PDF)
Zhong-Hao Ji, Wen-Zhi Ren, Shuo Yang, Dong-Xu Wang, Zi-Ping Jiang, Chao Lin, Ye Jin, Wen-Tai Tian: Identification of immune-related biomarkers associated with tumorigenesis and prognosis in skin cutaneous melanoma. Am J Cancer Res 2022;12(4):1727-1739. (Full text, PDF, Supplementary Table 1)
Ya-Jui Lin, Chiung-Yin Huang, Ya-Ching Shen, Kuo-Chen Wei, Chi-Cheng Chuang, Peng-Wei Hsu, Yin-Cheng Huang, Tsong-Long Hwang, Pin-Yuan Chen: A manzamine-derived compound as a potential therapeutic agent for glioma by inducing apoptosis and cell cycle arrest. Am J Cancer Res 2022;12(4):1740-1751. (Full text, PDF)
Xueling Yang, Guanglin Lei, Junxiao Wang, Zhenyu Wen, Zhenhu Ma, Yun Zhao, Hui Ren, Hui Xie: Integrative immunogenomic analysis reveals transcriptional and immune-related differences in hepatocellular carcinoma patients with different disease-free survival. Am J Cancer Res 2022;12(4):1752-1765. (Full text, PDF, Supplementary Table 2)
Yanan Cui, Pengpeng Zhang, Xiao Liang, Jiali Xu, Xinyin Liu, Yuemin Wu, Junling Zhang, Wei Wang, Fang Zhang, Renhua Guo: Association of KDR mutation with better clinical outcomes in pan-cancer for immune checkpoint inhibitors. Am J Cancer Res 2022;12(4):1766-1783. (Full text, PDF)
Madhuri Jayathirtha, Anca-Narcisa Neagu, Danielle Whitham, Shelby Alwine, Costel C Darie: Investigation of the effects of overexpression of jumping translocation breakpoint (JTB) protein in MCF7 cells for potential use as a biomarker in breast cancer. Am J Cancer Res 2022;12(4):1784-1823. (Full text, PDF)
Yongchen Guo, Chunna Ren, Wentao Huang, Wancai Yang, Yonghua Bao: Oncogenic ACSM1 in prostate cancer is through metabolic and extracellular matrix-receptor interaction signaling pathways. Am J Cancer Res 2022;12(4):1824-1842. (Full text, PDF)
Vincent Crenn, Jérôme Amiaud, Anne Gomez-Brouchet, Vincent Potiron, François Gouin, Philippe Rosset, Louis-Romée Le Nail, Luciano Vidal, Helios Bertin, Régis Brion, Guillaume Tran, Franck Verrecchia, Isabelle Corre, Françoise Redini: Signature of the vascular tumor microenvironment as a marker of the therapeutic response to doxorubicin in a preclinical model of osteosarcoma. Am J Cancer Res 2022;12(4):1843-1854. (Full text, PDF)
Liang Wang, Nan Dai, Dingrong Chen, Airui Jiang, Guobin Liao, Chaoqiang Fan, Xin Yang, Xue Peng, Xubiao Nie, Hui Lin, En Liu, Xi Liu, Xinwei Diao, Jianying Bai: Endoscopic features of esophageal high-grade intraepithelial neoplasia dominated by cytological atypia. Am J Cancer Res 2022;12(4):1855-1865. (Full text, PDF)
Xuemin Xue, Lin Dong, Edwina Burke, Liyan Xue, Yong-Jie Lu: The interaction of p53 and DNA repair gene mutations and their impact on tumor mutation burden and immune response in human malignancies. Am J Cancer Res 2022;12(4):1866-1883. (Full text, PDF)
Shih-Hung Yang, Nai-Jung Chiang, Sz-Chi Chiu, Wen-Chi Chou, Li-Yuan Bai, Chung-Pin Li, Yung-Yeh Su, Tai-Jan Chiu, Shih-Chang Chuang, Cheng-Ming Peng, De-Chuan Chan, Jen-Shi Chen, Chia-Jui Yen, Yen-Yang Chen, Chang-Fang Chiu, Li-Tzong Chen, Yan-Shen Shan: The impact of spleen volume on the survival of metastatic pancreatic adenocarcinoma patients receiving nanoliposomal irinotecan. Am J Cancer Res 2022;12(4):1884-1898. (Full text, PDF)
Wei Teng, Chen-Chun Lin, Chung-Wei Su, Po-Ting Lin, Yi-Chung Hsieh, Wei-Ting Chen, Ming-Mo Ho, Ching-Ting Wang, Pei-Mei Chai, Jason Chia-Hsun Hsieh, Chun-Yen Lin, Shi-Ming Lin: Combination of CRAFITY score with Alpha-fetoprotein response predicts a favorable outcome of atezolizumab plus bevacizumab for unresectable hepatocellular carcinoma. Am J Cancer Res 2022;12(4):1899-1911. (Full text, PDF)
Tony Reid, Bryan Oronsky, Nacer Abrouk, Scott Caroen, Pedro Cabrales: The small molecule NLRP3 inhibitor RRx-001 potentiates regorafenib activity and attenuates regorafenib-induced toxicity in mice bearing human colorectal cancer xenografts. Am J Cancer Res 2022;12(4):1912-1918. (Full text, PDF)
Akanksha Farswan, Anubha Gupta, Lingaraja Jena, Vivek Ruhela, Gurvinder Kaur, Ritu Gupta: Characterizing the mutational landscape of MM and its precursor MGUS. Am J Cancer Res 2022;12(4):1919-1933. (Full text, PDF)
