Juberiya M Azeez, Thachapillil Ramakrishnan Susmi, Viji Remadevi, Vini Ravindran, Anjana Sasikumar Sujatha, Raveendran nair Sobha Ayswarya, Sreeharshan Sreeja: New insights into the functions of progesterone receptor (PR) isoforms and progesterone signaling. Am J Cancer Res 2021;11(11):5214-5232. (Full text, PDF)
Neelum Aziz Yousafzai, Hongchuan Jin, Mujib Ullah, Xian Wang: Recent advances of SIRT1 and implications in chemotherapeutics resistance in cancer. Am J Cancer Res 2021;11(11):5233-5248. (Full text, PDF)
Daria Jach, Yuzhu Cheng, Filip Prica, Laurent Dumartin, Tatjana Crnogorac-Jurcevic: From development to cancer - an ever-increasing role of AGR2. Am J Cancer Res 2021;11(11):5249-5262. (Full text, PDF)
Dan Chen, Fengtao You, Shufen Xiang, Yinyan Wang, Yafen Li, Huimin Meng, Gangli An, Tingting Zhang, Zixuan Li, Licui Jiang, Hai Wu, Binjie Sheng, Bozhen Zhang, Lin Yang: Chimeric antigen receptor T cells derived from CD7 nanobody exhibit robust antitumor potential against CD7-positive malignancies. Am J Cancer Res 2021;11(11):5263-5281. (Full text, PDF)
Le Xu, Qingxiang Li, Yifei Wang, Lin Wang, Yuxing Guo, Rong Yang, Na Zhao, Na Ge, Yixiang Wang, Chuanbin Guo: m6A methyltransferase METTL3 promotes oral squamous cell carcinoma progression through enhancement of IGF2BP2-mediated SLC7A11 mRNA stability. Am J Cancer Res 2021;11(11):5282-5298. (Full text, PDF)
Akinchan Kumar, Yasenya Kasikci, Alaa Badredine, Karim Azzag, Marie L Quintyn Ranty, Falek Zaidi, Nathalie Aragou, Catherine Mazerolles, Bernard Malavaud, Marco A Mendoza-Parra, Laurence Vandel, Hinrich Gronemeyer: Patient-matched analysis identifies deregulated networks in prostate cancer to guide personalized therapeutic intervention. Am J Cancer Res 2021;11(11):5299-5318. (Full text, PDF, Supplementary File 1, 2, 3, 4, Tables 1-5)
Senbang Yao, Xiangxiang Yin, Tingting Chen, Wenjun Chen, He Zuo, Ziran Bi, Xiuqing Zhang, Yanyan Jing, Lulian Pang, Huaidong Cheng: ALDH2 is a prognostic biomarker and related with immune infiltrates in HCC. Am J Cancer Res 2021;11(11):5319-5337. (Full text, PDF)
Ni Chai, Yibai Xiong, Yuli Zhang, Yuelei Cheng, Wenfei Shi, Yiqing Yao, Hua Sui, Huirong Zhu: YYFZBJS inhibits colorectal tumorigenesis by remodeling gut microbiota and influence on M2 macrophage polarization in vivo and in vitro. Am J Cancer Res 2021;11(11):5338-5357. (Full text, PDF)
Ruixuan Wang, Tang Li, Guangren Li, Sheng-Xiang Lin: An unprecedented endocrine target for ovarian cancer: inhibiting 17β-HSD7 supresses cancer cell proliferation and arrests G2/M cycle. Am J Cancer Res 2021;11(11):5358-5373. (Full text, PDF)
Allison Staley, Katherine Tucker, Yajie Yin, Xin Zhang, Yali Fan, Yingao Zhang, Ziwei Fang, Wenchuan Sun, Hongyan Suo, Xiaoling Zhao, Ziyi Zhao, Varun Vijay Prabhu, Joshua E Allen, Chunxiao Zhou, Victoria L Bae-Jump: Highly potent dopamine receptor D2 antagonist ONC206 demonstrates anti-tumorigenic activity in endometrial cancer. Am J Cancer Res 2021;11(11):5374-5387. (Full text, PDF)
Kerry-Ann McDonald, Masanori Oshi, Tsutomu Kawaguchi, Qianya Qi, Xuan Peng, Akimitsu Yamada, Mateusz Opyrchal, Song Liu, Song Yao, Eigo Otsuji, Li Yan, Itaru Endo, Kazuaki Takabe: Development of KAM score to predict metastasis and worse survival in breast cancer. Am J Cancer Res 2021;11(11):5388-5401. (Full text, PDF)
Xianhui Ruan, Mengran Tian, Ning Kang, Weike Ma, Yu Zeng, Gaojian Zhuang, Wei Zhang, Guangwei Xu, Linfei Hu, Xiukun Hou, Wenjun Xie, Ming Gao, Yongjun Piao, Shicheng Guo, Xiangqian Zheng: Genome-wide identification of m6A-associated functional SNPs as potential functional variants for thyroid cancer. Am J Cancer Res 2021;11(11):5402-5414. (Full text, PDF)
Lulian Pang, Ziran Bi, Yanyan Jing, Xiangxiang Yin, Xiuqing Zhang, Senbang Yao, Jingjing Zhao, Huaidong Cheng: Changes in cytokine levels in breast cancer patients with CRCI before or after CALM intervention. Am J Cancer Res 2021;11(11):5415-5427. (Full text, PDF)
Chie Kudo-Saito, Yamato Ogiwara, Hiroshi Imazeki, Narikazu Boku, Yasushi Uemura, Rong Zhang, Akiko Kawano-Nagatsuma, Motohiro Kojima, Atsushi Ochiai: CD11b+DIP2A+LAG3+ cells facilitate immune dysfunction in colorectal cancer. Am J Cancer Res 2021;11(11):5428-5439. (Full text, PDF)
Jae Hee Lee, Byeongwook Jeon, Mijeong Park, Jimin Ha, Soo Jung Kim, Mi Kwon Son, Seungho Wang, Joo Han Lee, Youn Kyoung Jeong: Synergistic radiosensitizing effect of BR101801, a specific DNA-dependent protein kinase inhibitor, in various human solid cancer cells and xenografts. Am J Cancer Res 2021;11(11):5440-5451. (Full text, PDF)
Taylor E Arnoff, Wafik S El-Deiry: CDKN1A/p21WAF1, RB1, ARID1A, FLG, and HRNR mutation patterns provide insights into urinary tract environmental exposure carcinogenesis and potential treatment strategies. Am J Cancer Res 2021;11(11):5452-5471. (Full text, PDF)
Kuo-Chen Wei, You-Cheng Lin, Chia-Hua Chen, Yin-Hung Chu, Chiung-Yin Huang, Wen-Chieh Liao, Chiung-Hui Liu: Fucosyltransferase 8 modulates receptor tyrosine kinase activation and temozolomide resistance in glioblastoma cells. Am J Cancer Res 2021;11(11):5472-5484. (Full text, PDF)
JiHoon Kang, Ji-Hye Park, Jun Suk Kong, Min Jung Kim, Seung-Sook Lee, Sunhoo Park, Jae Kyung Myung: PINX1 promotes malignant transformation of thyroid cancer through the activation of the AKT/MAPK/β-catenin signaling pathway. Am J Cancer Res 2021;11(11):5485-5495. (Full text, PDF)
Yong Hyun Park, Jong In Lee, Ji Youl Lee, In Yae Cheong, Ji Hye Hwang, Seong Il Seo, Kang Hyun Lee, Ji Sung Yoo, Seung Hyun Chung, Yekyeong So: Internet of things-based lifestyle intervention for prostate cancer patients on androgen deprivation therapy: a prospective, multicenter, randomized trial. Am J Cancer Res 2021;11(11):5496-5507. (Full text, PDF)
Lianxiang Luo, Han Wang, Wen Tian, Jiayan Zeng, Yuru Huang, Hui Luo: Targeting ferroptosis for cancer therapy: iron metabolism and anticancer immunity. Am J Cancer Res 2021;11(11):5508-5525. (Full text, PDF)
Kuo-Cheng Wu, I-Cheng Lee, Chen-Ta Chi, Hao-Jan Lei, Gar-Yang Chau, Yi-Chen Yeh, Chien-Wei Su, Teh-Ia Huo, Yee Chao, Han-Chieh Lin, Ming-Chih Hou, Yi-Hsiang Huang: Comparable benefits of HCV eradication by direct acting antivirals and interferon-based therapy in patients with hepatocellular carcinoma undergoing surgical resection. Am J Cancer Res 2021;11(11):5526-5542. (Full text, PDF)
Concha López-Ginés, Lisandra Muñoz-Hidalgo, Teresa San-Miguel, Javier Megías, Juan Carlos Triviño, Silvia Calabuig, Pedro Roldán, Miguel Cerdá-Nicolás, Daniel Monleón: Whole-exome sequencing, EGFR amplification and infiltration patterns in human glioblastoma. Am J Cancer Res 2021;11(11):5543-5558. (Full text, PDF)
Huan-Song Yang, Bin Li, Shuang-Huan Liu, Miao Ao: Nomogram model for predicting postoperative survival of patients with stage IB-IIA cervical cancer. Am J Cancer Res 2021;11(11):5559-5570. (Full text, PDF)
Haiyan Liao, Songhua Cai, Yuezong Bai, Bei Zhang, Yuling Sheng, Shuang Tong, Jinping Cai, Feilong Zhao, Xiaochen Zhao, Shiqing Chen, Cheng Zhang, Jing Gao: Prevalence and spectrum of germline cancer susceptibility gene variants and somatic second hits in colorectal cancer. Am J Cancer Res 2021;11(11):5571-5580. (Full text, PDF)
Dominik Schulz, Guido Piontek, Ulrich M Zissler, Gabriele Multhoff, Markus Wirth, Anja Pickhard: MEK1/2 regulates APOBEC3B and polymerase iota-induced mutagenesis in head and neck cancer cells. Am J Cancer Res 2021;11(11):5581-5590. (Full text, PDF)
Lin Li, Suliman Khan, Song Li, Shengchun Wang, Fang Wang: Noncoding RNAs: emerging players in skin cancers pathogenesis. Am J Cancer Res 2021;11(11):5591-5608. (Full text, PDF)
Tai-Jan Chiu, Yi-Ju Chen, Jui Lan, Yen-Yang Chen, Yueh-Chiu Chen, Hsiao-Wu Lin, Hsin-Ting Tsai, Yu-Sheng Lin, Chang-Chun Hsiao, Chang-Han Chen: Downregulation of Notch3 links TIMP3 inhibition to suppress aggressive phenotypes of pancreatic ductal adenocarcinoma. Am J Cancer Res 2021;11(11):5609-5624. (Full text, PDF)
Maja S Misirkic Marjanovic, Ljubica M Vucicevic, Ana R Despotovic, Marina M Stamenkovic, Kristina D Janjetovic: Dual anticancer role of metformin: an old drug regulating AMPK dependent/independent pathways in metabolic, oncogenic/tumorsuppresing and immunity context. Am J Cancer Res 2021;11(11):5625-5643. (Full text, PDF)
He Wang, Samuel M DeFina, Manisha Bajpai, Qin Yan, Lei Yang, Zhongren Zhou: DNA methylation markers in esophageal cancer: an emerging tool for cancer surveillance and treatment. Am J Cancer Res 2021;11(11):5644-5658. (Full text, PDF)
Akanksha Farswan, Lingaraja Jena, Gurvinder Kaur, Anubha Gupta, Ritu Gupta, Lata Rani, Atul Sharma, Lalit Kumar: Branching clonal evolution patterns predominate mutational landscape in multiple myeloma. Am J Cancer Res 2021;11(11):5659-5679. (Full text, PDF, Supplementary Data)
Tarryn Willmer, Victoria Damerell, Shannon Smyly, Danica Sims, Michelle Du Toit, Stephanie Ncube, Musalula Sinkala, Dhirendra Govender, Edward Sturrock, Jonathan M Blackburn, Sharon Prince: Targeting the oncogenic TBX3:nucleolin complex to treat multiple sarcoma subtypes. Am J Cancer Res 2021;11(11):5680-5700. (Full text, PDF)
Weidong Wu, Nanding Yu, Feng Li, Pengqiang Gao, Shiyu Lin, Yong Zhu: RPL35 promotes neuroblastoma progression via the enhanced aerobic glycolysis. Am J Cancer Res 2021;11(11):5701-5714. (Full text, PDF)
Hongwen Cao, Dan Wang, Peng Sun, Lei Chen, Yigeng Feng, Renjie Gao: RNA-seq reveals microRNA-302b as a suppressor of prostate cancer epithelial-mesenchymal transition by targeting RELA/NF-κB. Am J Cancer Res 2021;11(11):5715-5725. (Full text, PDF)
Ying Chen, Zhongxin Feng, Xingyi Kuang, Peng Zhao, Bingqing Chen, Qin Fang, Weiwei Cheng, Jishi Wang: Increased lactate in AML blasts upregulates TOX expression, leading to exhaustion of CD8+ cytolytic T cells. Am J Cancer Res 2021;11(11):5726-5742. (Full text, PDF)
Yoshihisa Tokumaru, Masanori Oshi, Vijayashree Murthy, Wanqing Tian, Li Yan, Fernando A Angarita, Masayuki Nagahashi, Nobuhisa Matsuhashi, Manabu Futamura, Kazuhiro Yoshida, Yasuo Miyoshi, Kazuaki Takabe: Low intratumoral genetic neutrophil-to-lymphocyte ratio (NLR) is associated with favorable tumor immune microenvironment and with survival in triple negative breast cancer (TNBC). Am J Cancer Res 2021;11(11):5743-5755. (Full text, PDF)
Christopher G Hubert, Justin D Lathia: Identifying pediatric glioma’s Achilles heel through rational combination therapies. Am J Cancer Res 2021;11(11):5756-5758. (Full text, PDF)
Zheng Li, Yang Yang, Yang Gao, Xiaoliu Wu, Xielan Yang, Yingjie Zhu, Hongying Yang, Lin Wu, Chengang Yang, Libing Song: Elevated expression of flotillin-1 is associated with lymph node metastasis and poor prognosis in early-stage cervical cancer: Am J Cancer Res. 2016; 6(1): 38-50. Am J Cancer Res 2021;11(11):5759-5760. (Full text, PDF)
Bashir Lawal, Wen-Cheng Lo, Ntlotlang Mokgautsi, Maryam Rachmawati Sumitra, Harshita Khedkar, Alexander TH Wu, Hsu-Shan Huang: A preclinical report of a cobimetinib-inspired novel anticancer small-molecule scaffold of isoflavones, NSC777213, for targeting PI3K/AKT/mTOR/MEK in multiple cancers: Am J Cancer Res. 2021; 11(6): 2590-2617. Am J Cancer Res 2021;11(11):5761. (Full text, PDF)
